Molecular Analysis of Cancer Pdf

Molecular Analysis of Cancer Pdf

Molecular Analysis of Cancer Pdf

Molecular Analysis of Cancer Pdf

About the book:

Molecular Analysis of Cancer Book

Author: Carrie Fidler

Series: Methods in Molecular Medicine (Book 68)

Publisher: Humana; 2002 edition

Publish date: (October 10, 2001)

ISBN-10: 0896036227

ISBN-13: 978-0896036222

Pages: 304 eBook pages can be different

Language: English

Genres: Pathology

Review

Over the past 20 years, technological advances in molecular biology have proven invaluable to the understanding of the pathogenesis of human cancer. The application of molecular technology to the study of cancer has not only led to advances in tumor diagnosis, but has also provided markers for the assessment of prognosis and disease progression. The aim of Molecular Ana- sis of Cancer is to provide a comprehensive collection of the most up-to-date techniques for the detection of molecular changes in human cancer. Leading researchers in the field have contributed chapters detailing practical pro- dures for a wide range of state-of-the-art techniques. Molecular Analysis of Cancer includes chapters describing techniques for the identification of chromosomal abnormalities and comprising: fluor- cent in situ hybridization (FISH), spectral karyotyping (SKY), comparative genomic hybridization (CGH), and microsatellite analysis. FISH has a pro- nent role in the molecular analysis of cancer and can be used for the detection of numerical and structural chromosomal abnormalities. The recently described SKY, in which all human metaphase chromosomes are visualized in specific colors, allows for the definition of all chromosomal rearrangements and marker chromosomes in a tumor cell. Protocols for the detection of chromosomal re- rangements by PCR and RT-PCR are described, as well as the technique of DNA fingerprinting, a powerful tool for studying somatic genetic alterations in tumorigenesis.

Molecular Analysis of Cancer Pdf

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